P-P11 A tumour responsive, oxygen-generating nanoparticle to combat hypoxia in pancreatic tumours

Abstract Background Pancreatic cancer remains a significant therapeutic challenge and its poor prognosis has remained relatively unchanged for the past 40 years. tumours are highly desmoplastic impenetrable lesions in which both gas mass transfer is severely compromised. This leads to development of hypoxia within tumour this compromises approaches that rely on cytotoxic reactive oxygen species, e.g. photodynamic therapy, sonodynamic therapy radiotherapy. Hypoxia also results low pH microenvironment. Here we describe sensitive nanoparticle can generate enhance ROS generating approaches. Methods CaO2 NPs were generated by exposing frequency ultrasound subsequently coated using polymethacrylate polymer becomes soluble at 6.4. For some studies, sonosensitiser, Rose Bengal was attached particles. Oxygen generation (BxPC3) demonstrated inserting dissolved probe into following IV administration Particles employed together with (PDT) (SDT) human xenograft syngeneic pancreatic models. In cases, tissues recovered analysed infiltrating immune cells flow cytometry. Results Conclusions Coating nanoparticles provides situ tumours. Transient provision enhances therapies depend species. When used SDT, bilateral model, powerful abscopal effect observed shown be immune-mediated. The above data suggest particles may exploited other ROS, radiotherapy, further approach treat either local or disseminated forms cancer.